1 June 1992 Photosensitized inactivation of infectious agents for sterilization of red blood cell concentrates and whole blood
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Proceedings Volume 1650, Medical Lasers and Systems; (1992) https://doi.org/10.1117/12.137507
Event: OE/LASE '92, 1992, Los Angeles, CA, United States
Abstract
More than 10 million units of human blood components are transfused annually in the United States. Although donor screening and testing have greatly lowered the risk of transmission of viral and protozoan infectious agents, additional sterilization procedures which also preserve blood component function would be of significant value. Use of visible-light-range photosensitizers for sterilization of red blood cells is currently being aggressively investigated in laboratory-scale optical-mechanical systems. Both the photochemical sterilization process and the optical-mechanical system must operate without introducing significant alteration in the properties of the red cells. With successful demonstration of the efficacy and safety of these sterilization techniques, implementation in the blood bank setting will require scale-up to optical-mechanical systems capable of handling approximately 50,000 units daily in 500 - 1,000 blood banks in the United States.
© (1992) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Millard M. Judy, Millard M. Judy, James Lester Matthews, James Lester Matthews, Franklin M. Sogandares-Bernal, Franklin M. Sogandares-Bernal, Joseph T. Newman, Joseph T. Newman, Tran C. Chanh, Tran C. Chanh, Alain J. Marengo-Rowe, Alain J. Marengo-Rowe, } "Photosensitized inactivation of infectious agents for sterilization of red blood cell concentrates and whole blood", Proc. SPIE 1650, Medical Lasers and Systems, (1 June 1992); doi: 10.1117/12.137507; https://doi.org/10.1117/12.137507
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