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1 June 1992 Densitometric measurement of blood flow application to stenosis quantification
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A densitometric model was developed to estimate absolute blood flows in vessels from a DSA sequence. It is derived from the image intensity to contrast agent (CA) relationship and from the mass conservation law. We showed that the flow rate through a vascular cross section is determined from time summation (Phi) of densitometric areas within a single ROI. It also depends on the mass and the attenuation coefficient (mu) of CA and on acquisition conditions. After estimating the apparent value of (mu) , experiments with vessel phantoms were performed on DSA systems to validate this model. The effect of the distance between the injection site and the region of measurement, the magnification factor, the tubing cross-section area, the injected mass of iodine, and the flow rate of injected CA was tested and analyzed. The accuracy and the reproducibility of water flow rate measurements by this method were estimated and the deviations explained. Finally, we show how such experiments can be used to quantify a stenosis from a whole DSA image sequence. Area narrowing is equal to the ratio of the integrate terms (Phi) for reference and stenotic segments. Relative flows at a vessel bifurcation can also be estimated by applying the model to each segment.
© (1992) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Rozenn Le Goff and Yves J. Bizais "Densitometric measurement of blood flow application to stenosis quantification", Proc. SPIE 1652, Medical Imaging VI: Image Processing, (1 June 1992);

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