Densitometric measurement of blood flow application to stenosis quantification

Rozenn Le Goff; Yves J. Bizais

doi:10.1117/12.59447

Abstract

A densitometric model was developed to estimate absolute blood flows in vessels from a DSA sequence. It is derived from the image intensity to contrast agent (CA) relationship and from the mass conservation law. We showed that the flow rate through a vascular cross section is determined from time summation (Phi) of densitometric areas within a single ROI. It also depends on the mass and the attenuation coefficient (mu) of CA and on acquisition conditions. After estimating the apparent value of (mu) , experiments with vessel phantoms were performed on DSA systems to validate this model. The effect of the distance between the injection site and the region of measurement, the magnification factor, the tubing cross-section area, the injected mass of iodine, and the flow rate of injected CA was tested and analyzed. The accuracy and the reproducibility of water flow rate measurements by this method were estimated and the deviations explained. Finally, we show how such experiments can be used to quantify a stenosis from a whole DSA image sequence. Area narrowing is equal to the ratio of the integrate terms (Phi) for reference and stenotic segments. Relative flows at a vessel bifurcation can also be estimated by applying the model to each segment.

Citation Download Citation

Rozenn Le Goff, Rozenn Le Goff, Yves J. Bizais, Yves J. Bizais, } "Densitometric measurement of blood flow application to stenosis quantification", Proc. SPIE 1652, Medical Imaging VI: Image Processing, (1 June 1992); doi: 10.1117/12.59447; https://doi.org/10.1117/12.59447

ACCESS THE FULL ARTICLE

PERSONAL SIGN IN
Full access may be available with your subscription

Email or Username Forgot your username?

Password Forgot your password?

Show

Remember Email/Username on this computer

Remember Password

No SPIE account? Create an account
or Institutional Sign In via Shibboleth

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $14.40

Non-members: $18.00 ADD TO CART

Show All Keywords

Keywords/Phrases

Search In:

Publication Years