1 June 1992 Determination of left ventricular ejection fraction in technetium-99m-methoxy isobutyl isonitrile radionuclide angiocardiography
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Abstract
Abnormal left ventricular function is a diagnostic indication of cardiac disease. Left ventricular function is most commonly quantified by ejection fraction measurements. This paper presents a novel approach for the measurement of left ventricular ejection fraction (L VEF) using the recently introduced myocardial imaging agent, technetium-99m methoxy isobutyl isonitrile (99mTc-sestamibi). The approach utilizes computer image processing techniques to determine L VEF in equilibrium 99mTc-sestamibi multiple gated radionuclide angiography (RNA). Equilibrium RNA is preferred to first-pass RNA techniques due to the higher signal-to-noise ratio of equilibrium RNA resulting from longer image acquisition times. Data from 23 patients, symptomatic of cardiac disease, indicate that L VEFs determined using this radionuclide technique correlate well with contrast x-ray single plane cineangiography (r equals 0.83, p < 0.0000003).
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Malcolm H. Davis, Malcolm H. Davis, Bahman Rezaie, Bahman Rezaie, Frederick L. Weiland, Frederick L. Weiland, } "Determination of left ventricular ejection fraction in technetium-99m-methoxy isobutyl isonitrile radionuclide angiocardiography", Proc. SPIE 1652, Medical Imaging VI: Image Processing, (1 June 1992); doi: 10.1117/12.59459; https://doi.org/10.1117/12.59459
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