1 June 1992 Quantitative analysis of brain magnetic resonance imaging for hepatic encephalopathy
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High intensity lesions around ventricles have recently been observed in T1-weighted brain magnetic resonance images for patients suffering hepatic encephalopathy. The exact etiology that causes magnetic resonance imaging (MRI) gray scale changes has not been totally understood. The objective of our study was to investigate, through quantitative means, (1) the amount of changes to brain white matter due to the disease process, and (2) the extent and distribution of these high intensity lesions, since it is believed that the abnormality may not be entirely limited to the white matter only. Eleven patients with proven haptic encephalopathy and three normal persons without any evidence of liver abnormality constituted our current data base. Trans-axial, sagittal, and coronal brain MRI were obtained on a 1.5 Tesla scanner. All processing was carried out on a microcomputer-based image analysis system in an off-line manner. Histograms were decomposed into regular brain tissues and lesions. Gray scale ranges coded as lesion were then brought back to original images to identify distribution of abnormality. Our results indicated the disease process involved pallidus, mesencephalon, and subthalamic regions.
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Hon-Wei Syh, Hon-Wei Syh, Wei-Kom Chu, Wei-Kom Chu, Chin-Sing Ong, Chin-Sing Ong, "Quantitative analysis of brain magnetic resonance imaging for hepatic encephalopathy", Proc. SPIE 1652, Medical Imaging VI: Image Processing, (1 June 1992); doi: 10.1117/12.59415; https://doi.org/10.1117/12.59415

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