Currently a large European project in the area of PACS research and prototyping is being performed. The EurIPACS project is subdivided into a dozen topics. One of these topics is involved in the integration of PACS, RIS, and HIS on conceptual, functional, and technical levels. Within the scope of this topic, which is called HIPIN (HIs/ris-Pacs INtegration), a prototype PACS-RIS/HIS interface will be specified, designed, realized, clinically implemented, and evaluated. The interface software, together with the computer configuration on which it runs, is called the HIPIN box. This HIPIN box will be designed in such a way that it can be applied (with minimal adaptations) to interface any RIS/HIS with any PACS in a multi-vendor environment. Two incarnations of the HIPIN box will be realized and will be implemented in the clinical routines of a Belgian and a German hospital. The functionality of the interface will be focused to support the clinical requirements in these hospitals. The HIPIN box will support communication facilities, integration of the textural databases, and data- protection measures. Furthermore, it will contain intelligent modules to control image file archival and migration (prefetching).