2 March 1993 Integrated optic sensor with macro-flow cell
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Abstract
An integrated-optic channel waveguide device is configured as a biosensor. The device measures a refractive index change on the waveguide surface, so it is called a biorefractometer. With an appropriate overlay or selective coating, the device can monitor proteins in blood or pollutants and bio-warfare agents in water. We describe the design, fabrication, and testing of a sensor employing a waveguide Mach-Zehnder interferometer configuration. The device is fabricated in a glass substrate using potassium ion exchange. A patterned glass buffer layer defines the sensing and reference arms of the interferometer. A silicone-rubber macro-flow cell confines the liquid above the integrated-optical waveguide device. Salt solution data show that the biorefractometer has a sensitivity ((Delta) neff/(Delta) nLiquid) of 2 X 10-3 and can measure refractive index changes of about 0.005. Data obtained for antigen-antibody binding of the protein IgG indicate that a 10 percent signal change occurs in approximately 1 minute for a 10 (mu) g/ml concentration level.
© (1993) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Anthony A. Boiarski, James R. Busch, Ballwant S. Bhullar, Richard W. Ridgway, Van E. Wood, "Integrated optic sensor with macro-flow cell", Proc. SPIE 1793, Integrated Optics and Microstructures, (2 March 1993); doi: 10.1117/12.141217; https://doi.org/10.1117/12.141217
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