30 April 1993 Optical triple sensor for measuring pH, oxygen, and carbon dioxide in bioreactors
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Abstract
A triple sensor unit consisting of opto-chemical sensors for measurement of pH, oxygen, and carbon dioxide is presented. The pH sensor and the CO2 sensor are based on the color change of a pH-sensitive dye immobilized on a polymeric support. The resulting changes in absorption are monitored through optical fibers at one or two analytical wavelengths. The oxygen sensor is based on the quenching of the fluorescence of a metalorganic dye. The operation principle and the performance of all three sensors are described thoroughly with respect to their application in bioreactors. All three sensors are fully LED compatible. The chemical and mechanical stability, especially against common sterilization methods, are described in some detail. A calibration and measurement software comprising fit routines for the sensors and a mathematical treatment of the results are presented as well.
© (1993) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Bernhard H. Weigl, Bernhard H. Weigl, Andrej Holobar, Andrej Holobar, Wolfgang Trettnak, Wolfgang Trettnak, Ingo Klimant, Ingo Klimant, H. Kraus, H. Kraus, Paul O'Leary, Paul O'Leary, Otto S. Wolfbeis, Otto S. Wolfbeis, } "Optical triple sensor for measuring pH, oxygen, and carbon dioxide in bioreactors", Proc. SPIE 1796, Chemical, Biochemical, and Environmental Fiber Sensors IV, (30 April 1993); doi: 10.1117/12.143538; https://doi.org/10.1117/12.143538
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