The earliest laser application in medicine has occurred in ophthalmology. In 1965,the Shanghai Institute of Optics and Fine Mechanics, Academia Sinica, suy developed the first laser retina photocoagulator in China. It was an experimental prototype. Then the laser ophthalmic experiment for animal and for clinical demonstration were carried out at the Shanghai No. 6 People's Hospital. Since 1970 ,further effort has been made to improve the performances of this experimental system, and the ruby laser retina photocoagulator has been produced for clinic application. In 1972 ,a ruby laser photodisruptor was developed ,and was used for clinic peripheral iridectomy one year later. Since 1970,in addition to Shanghai,mo.st of the large cities of China,such as Beijing ,Shenyang,Guangzhou ,Hefei ,Chengdu and Xumou etc. successively started laser ophthalmology. Now the laser ophthalmology has become widespread medical application in China. The municipal hospitals of all provinces except Tibet and the suburban county hospitals have set up their laser ophthalmic clinics. As a regular medical technology ,laser has provided effective treatment for over thousand of the eye diseases patients every year. Among all cities of China , Shanghai is the leading and mo.st developed city in ophthalmology. 220 hospitals in Shanghai set up their laser clinics,and most of them has laser ophthalmic treatment divisions. Recently ,the Shanghai Research Center for Laser Medicine has been established in the Shanghai Second Medical University. The Center has assembled many famous laser medical experts and laser engineering experts. The ophthalmic laser application is its major effort.