Ophthalmic diagnostics using optical coherence tomography

Joseph A. Izatt; Michael R. Hee; David Huang; James G. Fujimoto; Eric A. Swanson; Charles P. Lin; Joel S. Shuman; Carmen A. Puliafito M.D.

doi:10.1117/12.147520

24 June 1993 Ophthalmic diagnostics using optical coherence tomography

Joseph A. Izatt, Michael R. Hee, David Huang, James G. Fujimoto, Eric A. Swanson, Charles P. Lin, Joel S. Shuman, Carmen A. Puliafito M.D.

Author Affiliations +

Proceedings Volume 1877, Ophthalmic Technologies III; (1993) https://doi.org/10.1117/12.147520
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

We present a new technique for coherent optical imaging of ocular structure based on optical coherence tomography (OCT). OCT is a noncontact, noninvasive, tomographic imaging technique with superior spatial resolution to ultrasound (< 20 micrometers ) and high sensitivity (100 dB dynamic range). We have used OCT to perform direct imaging of ocular structure in the anterior and posterior segments of human eyes in vitro and in vivo. In the anterior segment, we have measured corneal thickness and profile, anterior chamber depth and angle, and iris thickness and profile. These and other possible measurements have potential applications in diagnosis of pathologies of the cornea, angle, and iris, as well as in noncontact biometry for applications in cataract and corneal refractive surgeries. In the posterior segment, we have obtained high-resolution images of retinal structure in human subjects in vivo. These images demonstrate higher resolution than available with any other existing technique, and include characterization of optic disk morphology and topology. These measurements have potential applications in early diagnosis and assessment of glaucoma and other retinal diseases.

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Joseph A. Izatt, Michael R. Hee, David Huang, James G. Fujimoto, Eric A. Swanson, Charles P. Lin, Joel S. Shuman, and Carmen A. Puliafito M.D. "Ophthalmic diagnostics using optical coherence tomography", Proc. SPIE 1877, Ophthalmic Technologies III, (24 June 1993); https://doi.org/10.1117/12.147520

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