Acute effects of short-term intimal heating by laser-heated thermal balloon angioplasty in canine stenotic femoral arteries in vivo

Akira Miyamoto M.D.; Masami Sakurada; Tsunenori Arai; Kyoichi Mizuno; Yasunori Sugiyabu; Akira Kurita; Haruo Nakamura M.D.; Makoto Kikuchi; Tamishige Watanabe; Atsushi Utsumi; Yoshiro Akai; Kiyoshi Takeuchi

doi:10.1117/12.146577

23 June 1993 Acute effects of short-term intimal heating by laser-heated thermal balloon angioplasty in canine stenotic femoral arteries in vivo

Akira Miyamoto M.D., Masami Sakurada, Tsunenori Arai, Kyoichi Mizuno, Yasunori Sugiyabu, Akira Kurita, Haruo Nakamura M.D., Makoto Kikuchi, Tamishige Watanabe, Atsushi Utsumi, Yoshiro Akai, Kiyoshi Takeuchi

Author Affiliations +

Proceedings Volume 1878, Diagnostic and Therapeutic Cardiovascular Interventions III; (1993) https://doi.org/10.1117/12.146577
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

Short-term intimal heating may be effective to improve luminal geometry without deep medial injury which can induce restenosis. We developed a new laser-heated thermal balloon catheter which can quickly raise and lower the balloon temperature. To investigate the acute effect of short-term thermal balloon angioplasty (STBA) for stenotic lesions, we performed STBA following balloon angioplasty (BA) in 8 canine stenotic femoral arteries. Cw Nd:YAG laser delivery (10 W, 15 s) induced the maximum temperature of 83 degree(s)C on average. Angiography and angioscopy were performed at pre-BA, post-BA and post-STBA. The angiographical mean stenotic diameter was 1.8 mm at pre-BA, 2.2 mm* at post-BA, 2.9 mm** at post-STBA (*:p < 0.05 pre-BA vs post-BA, **:p < 0.05 pre- and post-BA vs post-STBA). The angioscopic observation revealed intimal flaps and tears in 7 lesions after BA. The luminal geometry after STBA was symmetrically expanded. However, the intimal injury was still observed although the intimal flaps were partly sealed by STBA. These results suggested that the dilatation mechanism of STBA for stenotic lesions might be attributed to preventing elastic recoil rather than to sealing intimal fragments induced by BA.

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Akira Miyamoto M.D., Masami Sakurada, Tsunenori Arai, Kyoichi Mizuno, Yasunori Sugiyabu, Akira Kurita, Haruo Nakamura M.D., Makoto Kikuchi, Tamishige Watanabe, Atsushi Utsumi, Yoshiro Akai, and Kiyoshi Takeuchi "Acute effects of short-term intimal heating by laser-heated thermal balloon angioplasty in canine stenotic femoral arteries in vivo", Proc. SPIE 1878, Diagnostic and Therapeutic Cardiovascular Interventions III, (23 June 1993); https://doi.org/10.1117/12.146577

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