23 June 1993 Evaluation of multidirectional fluorescence-sensing laser catheter for the development of an intelligent laser angioplasty system
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Proceedings Volume 1878, Diagnostic and Therapeutic Cardiovascular Interventions III; (1993); doi: 10.1117/12.146590
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States
Abstract
The differential diagnostic capacity of a multi-directional sensing catheter with intraluminal objects was evaluated by fluorescence analysis following administration of a photosensitizer. The measurement catheter is 1.7 mm in diameter and is constructed with a cross-sectional arrangement of 6 sensor bundle units and a centered guide wire lumen. Fluorescence was analyzed by polychrometer and amplified CCD camera with an image intensifier. The excitation light was 405 nm wavelength obtained from an Xe-Hg lamp using a band pass filter. In vivo and in vitro fluorescence analysis of normal and atherosclerotic rabbit aorta was performed following intravenous administration of 5 mg/kg hematoporphyrin derivatives (HpD) 24 hours before. The multi-directional sensing catheter detected fluorescence spectra independently in real time. In vivo measurement of this catheter showed, relative to the tip of catheter, in which direction there was blood, normal intima, slight intimal thickness, which should not be treated by laser, or areas of atherosclerosis, which can be treated by laser.
© (1993) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Takayuki Asahara, Mikio Usui, Takashi Amemiya, Yasuhisa Oike, Hiromori Shiraishi, Manabu Miyagi, Hitoshi Nakajima, Tomitsugu Kato, Yuichi Naito, Chiharu Ibukiyama, Katsuo Aizawa, Hiromi Tominaga, Isako Hoshino, "Evaluation of multidirectional fluorescence-sensing laser catheter for the development of an intelligent laser angioplasty system", Proc. SPIE 1878, Diagnostic and Therapeutic Cardiovascular Interventions III, (23 June 1993); doi: 10.1117/12.146590; https://doi.org/10.1117/12.146590
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KEYWORDS
Luminescence

Laser therapeutics

Intelligence systems

Diagnostics

Laser systems engineering

Blood

Fluorescence spectroscopy

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