Restenosis after pulsed laser irradiation

Jan Kvasnicka; Herbert J. Geschwind M.D.; Fumitaka Nakamura M.D.; Masakatsu Asada; Micheline Levame; Hassan Bousbaa

doi:10.1117/12.146578

23 June 1993 Restenosis after pulsed laser irradiation

Jan Kvasnicka, Herbert J. Geschwind M.D., Fumitaka Nakamura M.D., Masakatsu Asada, Micheline Levame, Hassan Bousbaa

Proceedings Volume 1878, Diagnostic and Therapeutic Cardiovascular Interventions III; (1993) https://doi.org/10.1117/12.146578
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

This study was designed to assess the depth and extent of chronic lesions induced by clinically relevant doses of excimer or Ho:YAG laser irradiation in an animal model of normal arterial wall. Normal iliac arteries of 14 male New Zealand rabbits were irradiated with excimer laser and 7 contralateral sites were irradiated with Ho:YAG laser. The lasers were coupled to a 1.4 and 1.5 mm multifiber wire guided catheter for excimer and Ho:YAG laser, respectively. The catheter was introduced through the carotid artery and positioned coaxially over the guide wire into the common iliac artery. After 28 days the irradiated sites were excised for light microscopy. Arterial wall lesions were assessed at the site of irradiation and at 30 mm antegrade to the site of intervention. (1) Excimer and Ho:YAG induce chronic arterial wall damage, which may result in accelerated restenosis. (2) Ho:YAG results in deeper and more extensive lesions than excimer. (3) Both lasers induce an initial vasodilation in the irradiated vessel which disappears at follow-up.

Citation Download Citation

Jan Kvasnicka, Herbert J. Geschwind M.D., Fumitaka Nakamura M.D., Masakatsu Asada, Micheline Levame, and Hassan Bousbaa "Restenosis after pulsed laser irradiation", Proc. SPIE 1878, Diagnostic and Therapeutic Cardiovascular Interventions III, (23 June 1993); https://doi.org/10.1117/12.146578

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available