Transmyocardial revascularization by a 1000-watt CO2 laser: sole therapy

John R. Crew M.D.; Marilyn Dean; Reinold Jones M.D.; John C. Fisher

doi:10.1117/12.146242

28 May 1993 Transmyocardial revascularization by a 1000-watt CO₂ laser: sole therapy (Abstract Only)

John R. Crew M.D., Marilyn Dean, Reinold Jones M.D., John C. Fisher

Proceedings Volume 1879, Lasers in Urology, Gynecology, and General Surgery; (1993) https://doi.org/10.1117/12.146242
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

The concept of transmyocardial revascularization (TMR) providing blood flow to the left heart muscle based on the reptilian heart model has now been extended from an adjunctive procedure with coronary artery bypass to sole therapy. At Seton Hospital and Medical Center TMR is now being performed for the first time in clinical trials with patients who have no other mechanism of perfusion and a history of either failed PTCA or coronary artery bypass, with angina already under maximum medical therapy with a demonstrable ischemic muscle target. Longevity and reperfusion by tomographic thallium of these laser-drilled holes has been previously demonstrated but effectiveness of these channels for primary perfusion (sole therapy) apart from normal coronary bypass collateral supply is under investigation. Phase I of the FDA study has been completed with 15 cases and now Phase II includes three other beta test sites along with alternative therapy in marginal cases as the investigational format for the next 50 cases. More than 2 year followup in the first 15 cases is presented.

Citation Download Citation

John R. Crew M.D., Marilyn Dean, Reinold Jones M.D., and John C. Fisher "Transmyocardial revascularization by a 1000-watt CO₂ laser: sole therapy (Abstract Only)", Proc. SPIE 1879, Lasers in Urology, Gynecology, and General Surgery, (28 May 1993); https://doi.org/10.1117/12.146242

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