Attempts to treat malignant melanoma by photodynamic therapy using bacteriopheophorbide ester as the sensitizer

Joerg G. Moser

doi:10.1117/12.146301

18 June 1993 Attempts to treat malignant melanoma by photodynamic therapy using bacteriopheophorbide ester as the sensitizer

Joerg G. Moser

Author Affiliations +

Proceedings Volume 1881, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II; (1993) https://doi.org/10.1117/12.146301
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

Quantitative data are presented on uptake and phototoxicity of the photosensitizing drug, 13² hydroxy bacteriopheophorbide a methyl ester, in three cell lines of melanotic (SkMel 25) and amelanotic (A375, Melur SP 18) melanoma. A375 is the most sensitive cell easily killed by irradiation with a laser diode at 775 nm by 2 J/cm². The Melur SP 18 cell line needs 5 J/cm² for the same effect. In both cases the decay of overliving cells obeys apparently the simple exponential law. In the melanotic SkMel 25 an overshoting plateau at low energy fluence was observed signalizing a metastatic potency induced by PDT. This is documented by a series of photographs. In principle, photosensitizing drugs with absorption maxima in the far red region are suitable to treat malignant melanoma with high efficiency. A method has to be developed to overcome PDT stimulation at low energy densities in melanotic melanoma.

Citation Download Citation

Joerg G. Moser "Attempts to treat malignant melanoma by photodynamic therapy using bacteriopheophorbide ester as the sensitizer", Proc. SPIE 1881, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II, (18 June 1993); https://doi.org/10.1117/12.146301

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