Medical applications of laser-induced fluorescence: pharmacokinetics of photosensitizers

Kevin T. Schomacker; Joan K. Frisoli; Thomas F. Deutsch

doi:10.1117/12.147686

7 July 1993 Medical applications of laser-induced fluorescence: pharmacokinetics of photosensitizers

Kevin T. Schomacker, Joan K. Frisoli, Thomas F. Deutsch

Proceedings Volume 1882, Laser-Tissue Interaction IV; (1993) https://doi.org/10.1117/12.147686
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

Laser-induced fluorescence has been used to measure tissue levels of chloroaluminum phthalocyanine tetrasulfonate versus time in order to determine its pharmacokinetics. A hamster cheek pouch carcinoma model was used in vivo. The data have been modeled using a four compartment pharmacokinetic model, yielding rate constants which describe the transport. A minimum of 13 rate constants was needed to achieve acceptable fits to the tumor and normal tissue as well as plasma data. The model gives insight into the role of binding and unbinding processes that are not otherwise evident.

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Kevin T. Schomacker, Joan K. Frisoli, and Thomas F. Deutsch "Medical applications of laser-induced fluorescence: pharmacokinetics of photosensitizers", Proc. SPIE 1882, Laser-Tissue Interaction IV, (7 July 1993); https://doi.org/10.1117/12.147686

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