Relaxation dynamic measurements in fibrin networks

Giuseppe Arcovito; F. Andreasi Bassi; Marco De Spirito

doi:10.1117/12.148374

21 July 1993 Relaxation dynamic measurements in fibrin networks

Giuseppe Arcovito, F. Andreasi Bassi, Marco De Spirito

Proceedings Volume 1884, Static and Dynamic Light Scattering in Medicine and Biology; (1993) https://doi.org/10.1117/12.148374
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

Quasi-elastic light scattering measurements of the normalized time-dependent density correlation function, g(t), have been carried out on fibrin networks formed at T equals 25 degree(s)C from fibrinogen solutions. Fibrinogen is a protein present in vertebrate body fluids, which is capable of forming gels because of an initial activation and a successive polymerization process. The correlation function g(t) has been systematically measured as a function of the fibrinogen concentration in solutions at a fixed pH 8, activated by 400 nM of thrombin. As the fibrinogen concentration increases from 84.5 nM to 880 nM, g(t) exhibits pronounced nonexponential relaxation. The stretched exponential function e^-(t/τ) ^β has been shown to fit the g(t) function over a four decade time range of measurement, for q values ranging between 1.32 X 10⁵ cm^-1 and 2.45 X 10⁵ cm^-1 stretched exponent (beta) equals 0.65 +/- 0.05, commonly observed near the glass transition point, has been obtained. The average decay rate (lambda), accounting for short time decay rates of g(t), decreases as concentration increases showing a minimum at p equals 400 +/- 50 nM, while the relaxation time τ shows a maximum at the same concentration.

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Giuseppe Arcovito, F. Andreasi Bassi, and Marco De Spirito "Relaxation dynamic measurements in fibrin networks", Proc. SPIE 1884, Static and Dynamic Light Scattering in Medicine and Biology, (21 July 1993); https://doi.org/10.1117/12.148374

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