Colorimetric blood-gas monitoring sensors

Keith J. Proctor; George P. Seifert

doi:10.1117/12.144825

21 May 1993 Colorimetric blood-gas monitoring sensors

Keith J. Proctor, George P. Seifert

Proceedings Volume 1886, Fiber Optic Sensors in Medical Diagnostics; (1993) https://doi.org/10.1117/12.144825
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

Colorimetric fiber optic sensors have been developed for measuring the pH and pCO₂ of blood. These sensors are fabricated using a single 125 micrometers diameter optical fiber. Located at the distal end of the fiber is a capsule that contains a pH sensitive dye. The pCO₂ sensor is fabricated from a pH sensor with the addition of a salt, bicarbonate, and the encapsulation with an ion impermeable gas permeable membrane. The distal end of the capsule is terminated with a reflective surface. The reflective surface can either be a polished metallic surface or, in this case, a TiO₂ impregnated epoxy. The disposable sensor mates with an optical connector that contains two optical fibers of the same size as the disposable sensor. The two fibers within the optical cable provide a light path for both the antegrade and retrograde optical signals. These fibers are terminated at either the LED source or the detector. A prototype sensor assembly that incorporates the measurement of three physiological parameters (pH, pCO₂, and sO₂) has been demonstrated to fit within a standard 20 gauge arterial catheter, typically used for radial artery blood pressure monitoring, without significant damping of the blood pressure waveform. The pH sensor has a range of 6.9 - 7.8 with a precision of 0.01 pH units and the pCO₂ sensor has a range of 15 - 95 mm Hg with a precision of 3 mm Hg. The long term drift pH drift is less than 0.01 pH unit per 8 hours and the pCO₂ drift is less than 1 mm Hg per 8 hours. Sensor performance in the canine has demonstrated that the pH sensor is accurate to within +/- 0.03 pH units and the pCO₂ sensor is accurate to within +/- 3 mm Hg when compared to a typical blood gas analyzer.

Citation Download Citation

Keith J. Proctor and George P. Seifert "Colorimetric blood-gas monitoring sensors", Proc. SPIE 1886, Fiber Optic Sensors in Medical Diagnostics, (21 May 1993); https://doi.org/10.1117/12.144825

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