NIR Raman and fluorescence spectroscopies diagnose cancer!

C. H. Liu; Bidyut Baran Das; Wenling S. Glassman; Gui Chen Tang; Han-Ru Zhu; Daniel L. Akins; Stephanie Lubicz M.D.; Joseph Cleary M.D.; R. Prudente M.D.; Edward J. Celmer M.D.; E. Caron; Robert R. Alfano

doi:10.1117/12.151201

27 August 1993 NIR Raman and fluorescence spectroscopies diagnose cancer!

C. H. Liu, Bidyut Baran Das, Wenling S. Glassman, Gui Chen Tang, Han-Ru Zhu, Daniel L. Akins, Stephanie Lubicz M.D., Joseph Cleary M.D., R. Prudente M.D., Edward J. Celmer M.D., E. Caron, Robert R. Alfano

Author Affiliations +

Proceedings Volume 1887, Physiological Imaging, Spectroscopy, and Early-Detection Diagnostic Methods; (1993) https://doi.org/10.1117/12.151201
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

NIR Raman scattering and fluorescence were investigated from malignant and normal biomedical media. Raman spectra were obtained from human normal, benign and cancerous tissues of the gynecological (GYN) tracts. Comparing the differences in intensity for the different Raman modes as well as the difference between the number of Raman lines, the normal (GYN) tissues can be distinguished from the malignant tissues. The fluorescence spectra from human breast tissues that were obtained showed that the ratio of fluorescence intensities at 340 nm to 440 nm can be used to distinguish between malignant and non- malignant tissues. Separate studies from normal and malignant breast cell lines show spectral differences assigned to NADH and flavins. These studies show that various optical techniques have the potential to be useful in medical diagnostic applications.

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C. H. Liu, Bidyut Baran Das, Wenling S. Glassman, Gui Chen Tang, Han-Ru Zhu, Daniel L. Akins, Stephanie Lubicz M.D., Joseph Cleary M.D., R. Prudente M.D., Edward J. Celmer M.D., E. Caron, and Robert R. Alfano "NIR Raman and fluorescence spectroscopies diagnose cancer!", Proc. SPIE 1887, Physiological Imaging, Spectroscopy, and Early-Detection Diagnostic Methods, (27 August 1993); https://doi.org/10.1117/12.151201

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