Quantification of tissue chromophore concentration via water-peak measurements in near-infrared spectroscopy

Steven J. Matcher; Mark Cope; David T. Delpy

doi:10.1117/12.154639

14 September 1993 Quantification of tissue chromophore concentration via water-peak measurements in near-infrared spectroscopy

Steven J. Matcher, Mark Cope, David T. Delpy

Author Affiliations +

Proceedings Volume 1888, Photon Migration and Imaging in Random Media and Tissues; (1993) https://doi.org/10.1117/12.154639
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

We describe a simple method for measuring the differential pathlength of photons in a scattering medium utilizing the absorption features of water. The method allows quantification of chromophore concentration changes measured by near infrared spectroscopy without the need for time- or frequency-resolved measurements. We present the results of validation experiments performed on tissue phantoms and in-vivo comparisons between the differential path estimates yielded by water absorption and time-resolved measurements. We discus the accuracy of the differential path estimates provided by both the 975 nm and the 840 nm water features, finding that while the 840 nm feature is measured with lower accuracy for a given light flux, it is intrinsically a more accurate differential path estimator.

Citation Download Citation

Steven J. Matcher, Mark Cope, and David T. Delpy "Quantification of tissue chromophore concentration via water-peak measurements in near-infrared spectroscopy", Proc. SPIE 1888, Photon Migration and Imaging in Random Media and Tissues, (14 September 1993); https://doi.org/10.1117/12.154639

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available