Biphotonic reactions of a dihydropyridine derivative of AZT related to AIDS dementia

L. Lindqvist; B. Czochralska; W. Kawczynski

doi:10.1117/12.146200

17 June 1993 Biphotonic reactions of a dihydropyridine derivative of AZT related to AIDS dementia

L. Lindqvist, B. Czochralska, W. Kawczynski

Proceedings Volume 1922, Laser Study of Macroscopic Biosystems; (1993) https://doi.org/10.1117/12.146200
Event: Laser Spectroscopy of Biomolecules: 4th International Conference on Laser Applications in Life Sciences, 1992, Jyvaskyla, Finland

Abstract

It was shown that exposure of the AZT derivative 5'-(1,4-dihydro-1-methyl-3- pyridinyl-carbonyl)-3'-azido-2', 3'-dideoxythymidine) (H₂PyrAZT) in aqueous solution to pulsed laser emission ((lambda) equals 355 nm, pulse length 2 ns) gives rise to photoelectron ejection by stepwise two-photon absorption. Absorption spectra of the semioxidized radicals obtained in this reaction were determined. It was shown that the photolysis did not affect the azido group.

Citation Download Citation

L. Lindqvist, B. Czochralska, and W. Kawczynski "Biphotonic reactions of a dihydropyridine derivative of AZT related to AIDS dementia", Proc. SPIE 1922, Laser Study of Macroscopic Biosystems, (17 June 1993); https://doi.org/10.1117/12.146200

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