17 June 1993 Nonlinear spectroscopy of chiral molecules: new spectroscopic techniques for studying left-right mirror asymmetry of biological molecules
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Proceedings Volume 1922, Laser Study of Macroscopic Biosystems; (1993); doi: 10.1117/12.146177
Event: Laser Spectroscopy of Biomolecules: 4th International Conference on Laser Applications in Life Sciences, 1992, Jyvaskyla, Finland
Abstract
Molecular left-right asymmetry is an origin of nonvanishing even order optical nonlinear susceptibilities of non-racemic solutions of chiral molecules. New non-linear optical spectroscopic schemes based on three- and five-wave interactions in chiral homogeneous isotropic media (symmetry forbidden in centrosymmetric racemic solutions) are investigated with the aim to develop a novel technique to clearly distinguish between left and right mirror isomers of biological molecules and to measure their individual nonlinear optical hyperpolarizabilities, and vibrational spectra. Through second harmonic generation (SHG) due to quadratic dipolar nonlinearity is still symmetry forbidden in optically active liquids yet we have succeeded in experimental observation, for the first time, of noncollinear SHG due to five-mixing process according to a scheme 2(omega) equals 3(omega) - (omega) , governed by a fourth order susceptibility tensor (chi) (4D). SHG signal is found to be well collimated and quasi phase-matched, it shows theoretically predicted polarization, spectral and temporal properties.
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A. V. Dubrovskii, Nikolai I. Koroteev, Aleksandr P. Shkurinov, "Nonlinear spectroscopy of chiral molecules: new spectroscopic techniques for studying left-right mirror asymmetry of biological molecules", Proc. SPIE 1922, Laser Study of Macroscopic Biosystems, (17 June 1993); doi: 10.1117/12.146177; https://doi.org/10.1117/12.146177
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KEYWORDS
Molecular spectroscopy

Second-harmonic generation

Polarization

Molecules

Spectroscopy

Liquids

Nonlinear optics

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