The Precision Optical Interferometer in Space (POINTS) is a free flying, space-based, astrometric interferometry mission employing an instrument with two 2-meter baseline interferometers. This paper addresses a disturbance analysis of the preliminary POINTS spacecraft and instrument design in order to determine whether and to what extent any isolation and/or added structural damping is necessary to meet the POINTS instrument requirements. The analysis was performed using the Integrated Modeling of Optical Systems (IMOS) integrated modeling tool. IMOS is an integrated software environment wherein structural, optical, and control system modeling can be performed. Linearized optical models, structural finite element models, and disturbance characterization models were developed and integrated in IMOS. Starlight fringe coherence was used as a metric to quantify the performance of the POINTS instrument. Linear optical perturbation analysis gave insight into the sensitivity of the performance of the interferometers to perturbations of the positions and orientations of the optical elements. Finite element modal analysis yielded structural modes, modeshapes, modal costs, and Hankel singular values. These models were integrated with the disturbance models allowing for generation of frequency response functions. The result of this analysis is end-to-end disturbance characterizations (starlight fringe coherence as a function of reaction wheel speed, for example).