23 June 1993 Statistical methods for paired comparisons of SPECT brain images
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We develop and apply several straightforward statistical tools--analyses of rigid body motions, linear deformations, and morphological operations (histogram equalization, dilation, medial axis transform)--to single photon emission computed tomography (SPECT) images arising in the clinical investigation of brain lesions. Examples derive from a simulation of relevant clinical features using a physical head phantom and with paired SPECT images of the same patient recorded over time.
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Nicholas Lange, L. A. O'Tuama, S. Ted Treves, "Statistical methods for paired comparisons of SPECT brain images", Proc. SPIE 2035, Mathematical Methods in Medical Imaging II, (23 June 1993); doi: 10.1117/12.146599; https://doi.org/10.1117/12.146599

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