10 March 1994 Monitoring of fermentation parameters with fiber optics
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Proceedings Volume 2068, Chemical, Biochemical, and Environmental Fiber Sensors V; (1994) https://doi.org/10.1117/12.170688
Event: Optical Tools for Manufacturing and Advanced Automation, 1993, Boston, MA, United States
Bioprocess control requires reliable and continuous monitoring of nutrients and various process parameters, such as dissolved oxygen, carbon dioxide, and pH. Currently, the on-line control of these parameters is achieved electrochemically via dip-in electrodes or indirectly by off-gas analysis. Optical sensors offer an alternative to these conventional methods. Fiber- optic sensors for measuring pH, CO2 and O2 have been developed. We have demonstrated the use of a fiber-optic sensor for the continuous monitoring of fermentation pH. In this paper we discuss the use of a ratiometric method and medium calibration as a way to improve the precision of the fiber-optic sensor.
© (1994) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Venetka I. Agayn, Venetka I. Agayn, David R. Walt, David R. Walt, } "Monitoring of fermentation parameters with fiber optics", Proc. SPIE 2068, Chemical, Biochemical, and Environmental Fiber Sensors V, (10 March 1994); doi: 10.1117/12.170688; https://doi.org/10.1117/12.170688

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