Near-field fiber optic chemical sensors and biological applications

Weihong Tan; Zhong-You Shi; Bjorn A. Thorsrud; C. Harris; Raoul Kopelman

doi:10.1117/12.170651

10 March 1994 Near-field fiber optic chemical sensors and biological applications

Weihong Tan, Zhong-You Shi, Bjorn A. Thorsrud, C. Harris, Raoul Kopelman

Proceedings Volume 2068, Chemical, Biochemical, and Environmental Fiber Sensors V; (1994) https://doi.org/10.1117/12.170651
Event: Optical Tools for Manufacturing and Advanced Automation, 1993, Boston, MA, United States

Abstract

Near-field optics has been applied in the nanofabrication of subwavelength optical fiber chemical and biological sensors and their operation in chemical and biological analysis. A thousandfold miniaturization of immobilized optical fiber sensors has been achieved by a near- field photo-nanofabrication technique, which is based on nanofabricated optical fiber tips and near-field photopolymerization. This technique has been further developed by multistep near- field nanofabrication and multidye probe fabrication. Multistep nanofabrication can further miniaturize optical fiber sensors, while multidye fabrication results in multifunctional optic and excitonic probes with extremely small size. These probes emit multiwavelength photons or produce excitons of different energy levels, and may have multiple chemical or biological sensitivities. The nondestructive submicrometer sensor has demonstrated its ability to carry out static and dynamic determinations of pH in intact rat conceptuses of varying gestational ages. The ability of the sensors to measure pH changes, in real time, in the intact rat conceptus, demonstrates their potential applications for dynamic analysis in multicellular organisms and single cells. The near-field interaction of photons with matter is discussed.

Citation Download Citation

Weihong Tan, Zhong-You Shi, Bjorn A. Thorsrud, C. Harris, and Raoul Kopelman "Near-field fiber optic chemical sensors and biological applications", Proc. SPIE 2068, Chemical, Biochemical, and Environmental Fiber Sensors V, (10 March 1994); https://doi.org/10.1117/12.170651

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