1 March 1994 Biodistribution detection of Photofrin porfimer sodium and benzoporphyrin derivative using a fiber optic sensor and ratio fluorometry
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Proceedings Volume 2078, Photodynamic Therapy of Cancer; (1994) https://doi.org/10.1117/12.168656
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary
Abstract
Laser induced fluorescence spectroscopy (LIFS) was used to detect the presence of PHOTOFRINR porfimer sodium and Benzoporphyrin derivative-monoacid, ring A (BPD-MA) in various tissues. Lobund Wistar rats (n equals 49) inoculated with rat prostatic adenocarcinoma (PA-III) were injected with PHOTOFRINR porfimer sodium (7.5 - 0.25 mg/kg) and BPD (0.50 - 25 mg/kg) intravenously. A Helium-Cadmium laser (442 nm) was used as an excitation source. Our study showed that the amount of PHOTOFRINR porfimer sodium and BPD-MA which localizes in the metastatic lymph nodes is higher than in tumor and all other healthy tissues. Laser induced fluorescence spectroscopy may be a feasible method to detect the distribution of photosensitizers or other fluorescent compounds in vivo.
© (1994) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Sandor G. Vari, Theodore G. Papazoglou, Thanassis Papaioannou, Marigo Stavridi, Vani R. Pergadia, Michael C. Fishbein, Maurits J. van der Veen, Reem Thomas, Warren S. Grundfest, "Biodistribution detection of Photofrin porfimer sodium and benzoporphyrin derivative using a fiber optic sensor and ratio fluorometry", Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); doi: 10.1117/12.168656; https://doi.org/10.1117/12.168656
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