Effect of sulfonation on the photosensitizing efficiency of aluminum phthalocyanine and meso-tetraphenylporphine in photodynamic therapy of cancer

Qian Peng; Li Wei Ma; Kristian Berg; Johan Moan

doi:10.1117/12.168662

1 March 1994 Effect of sulfonation on the photosensitizing efficiency of aluminum phthalocyanine and meso-tetraphenylporphine in photodynamic therapy of cancer

Qian Peng, Li Wei Ma, Kristian Berg, Johan Moan

Author Affiliations +

Proceedings Volume 2078, Photodynamic Therapy of Cancer; (1994) https://doi.org/10.1117/12.168662
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary

Abstract

The effect of sulfonations on the PDT efficiency of aluminum phthalocyanines and meso- tetraphenylporphines was studied in the CaD2 mouse mammary carcinoma. The PDT efficiencies were found to decrease in the following order: AlPCS₂ > AlPCS₄ > Photofrin > TPPS_2a > AlPCS₁ > TPPS₄ > TPPS_2o > TPPS₁. Apparently, the degree of sulfonations of both families of dyes strongly affects the photobiological properties. It was found to be of great importance whether the sulfonate groups were located adjacently or opposite positions on the molecules.

Citation Download Citation

Qian Peng, Li Wei Ma, Kristian Berg, and Johan Moan "Effect of sulfonation on the photosensitizing efficiency of aluminum phthalocyanine and meso-tetraphenylporphine in photodynamic therapy of cancer", Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); https://doi.org/10.1117/12.168662

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