Highly substituted phthalocyanine derivatives as potential photosensitizers for photodynamic therapy of tumors

Michael J. Cook; Clara Fabris; Cristina Ometto; Denise A. Mayes; Giulio Jori; Jim McMurdo; Carla Milanesi; David A. Russell

doi:10.1117/12.168705

1 March 1994 Highly substituted phthalocyanine derivatives as potential photosensitizers for photodynamic therapy of tumors

Michael J. Cook, Clara Fabris, Cristina Ometto, Denise A. Mayes, Giulio Jori, Jim McMurdo, Carla Milanesi, David A. Russell

Author Affiliations +

Proceedings Volume 2078, Photodynamic Therapy of Cancer; (1994) https://doi.org/10.1117/12.168705
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary

Abstract

An octakis-decyl-substituted Zn(II)-phthalocyanine (ZnODPc) was prepared by chemical synthesis and was shown to possess favorable photophysical properties to act as a photodynamic agent. Intravenous injection of ZnODPc incorporated into Cremophor emulsions (1.2 or 2.4 mg/kg) to Balb/c mice bearing a MS-2 fibrosarcoma resulted in an efficient and selective accumulation of the phthalocyanine in the tumor. Illumination of the ZnODPc-loaded neoplastic lesion at 24 h after injection caused tumor regression as a result of both intracellular and intravascular damage.

Citation Download Citation

Michael J. Cook, Clara Fabris, Cristina Ometto, Denise A. Mayes, Giulio Jori, Jim McMurdo, Carla Milanesi, and David A. Russell "Highly substituted phthalocyanine derivatives as potential photosensitizers for photodynamic therapy of tumors", Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); https://doi.org/10.1117/12.168705

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