1 March 1994 Highly substituted phthalocyanine derivatives as potential photosensitizers for photodynamic therapy of tumors
Author Affiliations +
Proceedings Volume 2078, Photodynamic Therapy of Cancer; (1994) https://doi.org/10.1117/12.168705
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary
Abstract
An octakis-decyl-substituted Zn(II)-phthalocyanine (ZnODPc) was prepared by chemical synthesis and was shown to possess favorable photophysical properties to act as a photodynamic agent. Intravenous injection of ZnODPc incorporated into Cremophor emulsions (1.2 or 2.4 mg/kg) to Balb/c mice bearing a MS-2 fibrosarcoma resulted in an efficient and selective accumulation of the phthalocyanine in the tumor. Illumination of the ZnODPc-loaded neoplastic lesion at 24 h after injection caused tumor regression as a result of both intracellular and intravascular damage.
© (1994) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Michael J. Cook, Michael J. Cook, Clara Fabris, Clara Fabris, Cristina Ometto, Cristina Ometto, Denise A. Mayes, Denise A. Mayes, Giulio Jori, Giulio Jori, Jim McMurdo, Jim McMurdo, Carla Milanesi, Carla Milanesi, David A. Russell, David A. Russell, } "Highly substituted phthalocyanine derivatives as potential photosensitizers for photodynamic therapy of tumors", Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); doi: 10.1117/12.168705; https://doi.org/10.1117/12.168705
PROCEEDINGS
8 PAGES


SHARE
Back to Top