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1 March 1994 Induction of protoporphyrin biosynthesis and photodynamic inactivation of B16 melanoma cells
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Proceedings Volume 2078, Photodynamic Therapy of Cancer; (1994) https://doi.org/10.1117/12.168674
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary
Abstract
The induction of protoporphyrin (PP) synthesis in B16 melanoma cells and their subsequent photodestruction was investigated. Photosensitized cells gradually disintegrated following prolonged irradiation. The photosensitized cells showed an immediate potassium loss compensated only partially by influx of Na and other ions. The dominant characteristics of these cells were potassium efflux, water influx and ultrastructural damage in subcellular compartments. In conclusion, a highly efficient system for killing B16 melanoma cells was achieved by photosensitization of endogenous PP produced subsequent to chemical induction.
© (1994) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Zvi Malik, T. Babushkina, M. Shafran, Y. Nordenberg, R. Mamet, and N. Schoenfeld "Induction of protoporphyrin biosynthesis and photodynamic inactivation of B16 melanoma cells", Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); https://doi.org/10.1117/12.168674
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