Light dosimetry for photodynamic therapy of superficial tumors in the bladder

Wolfgang Beyer; T. Pongratz; Alfons G. Hofstetter; Dieter Jocham; Eberhard Unsoeld

doi:10.1117/12.168714

1 March 1994 Light dosimetry for photodynamic therapy of superficial tumors in the bladder

Wolfgang Beyer, T. Pongratz, Alfons G. Hofstetter, Dieter Jocham, Eberhard Unsoeld

Proceedings Volume 2078, Photodynamic Therapy of Cancer; (1994) https://doi.org/10.1117/12.168714
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary

Abstract

Photodynamic therapy (PDT) of tumors in the urinary bladder requires a homogeneous light distribution on the whole organ wall. The light applicator recently developed consists of a catheter-supported isotropic emitter and a concentric outer balloon, which guarantees a centric position. For dosimetry a detector fiber with conical end is axially placed half way between center and bladder outlet. It detects the light backscattered from the bladder wall. It has been tested by means of a bladder phantom model with variable backscattering properties. To study the limits of this irradiation and dosimetry concept in case of nonspherical bladder shapes the light distributions in hollow ellipsoids with backscattering surface have been investigated by computer simulation. It shows that the ratio of the largest to the smallest fluence rate and the ratio of the largest to the smallest diameter of the bladder are nearly equal.

Citation Download Citation

Wolfgang Beyer, T. Pongratz, Alfons G. Hofstetter, Dieter Jocham, and Eberhard Unsoeld "Light dosimetry for photodynamic therapy of superficial tumors in the bladder", Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); https://doi.org/10.1117/12.168714

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