1 March 1994 Photodynamic laser therapy with antibody-coupled phthalocyanine
Author Affiliations +
Proceedings Volume 2078, Photodynamic Therapy of Cancer; (1994) https://doi.org/10.1117/12.168709
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary
We developed a new water-soluble phthalocyanine, activated for coupling to antibodies by N- hydroxysulfosuccinimide. The efficiency of anti-CA125-phthalocyanine conjugates was compared to free phthalocyanine in a human ovarian carcinoma model in tissue culture. In both cases a dose dependent cell killing was observed after irradiation with a Titanium sapphire laser at 675 nm and 50 J/cm2, but incubation with antibody-coupled phthalocyanine resulted in 90% cell mortality with a 60-130-fold lower dye application.
© (1994) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Birgit C. Schultes, Birgit C. Schultes, Stefan B. Spaniol, Stefan B. Spaniol, Stephan Schmidt, Stephan Schmidt, Wolfgang Ertmer, Wolfgang Ertmer, Hans-Juergen Biersack, Hans-Juergen Biersack, Dieter Krebs, Dieter Krebs, "Photodynamic laser therapy with antibody-coupled phthalocyanine", Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); doi: 10.1117/12.168709; https://doi.org/10.1117/12.168709

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