Photodynamic therapy: light dosimetry and laser-induced tissue temperature phenomena

Natalia Filonenko; Y. Gurevich; Norman M. Salansky

doi:10.1117/12.168692

1 March 1994 Photodynamic therapy: light dosimetry and laser-induced tissue temperature phenomena

Natalia Filonenko, Y. Gurevich, Norman M. Salansky

Proceedings Volume 2078, Photodynamic Therapy of Cancer; (1994) https://doi.org/10.1117/12.168692
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary

Abstract

Laser induced localized temperature distribution control in tissue could for instance provide in the targeted (e.g. tumor) area maximum sets of values to be used in efficacy increase for photodynamic therapy (PD) and hyperthermia (HT) applications. Spatial temperature distribution calculation method based on analytical solution of heat transfer equation is presented for laser induced heating and external tissue surface cooling combination. This method was applied to provide maximum temperature increase in deep tissue layers. Analytical relations for laser beam parameters and temperature threshold diagrams are obtained. These diagrams are to be used to avoid tissue burn. Examples of temperature increase in deep tissue layers are presented.

Citation Download Citation

Natalia Filonenko, Y. Gurevich, and Norman M. Salansky "Photodynamic therapy: light dosimetry and laser-induced tissue temperature phenomena", Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); https://doi.org/10.1117/12.168692

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