Computer tomography assisted laser intervention

Adam R. Mester; Ernoe Mako

doi:10.1117/12.167322

1 February 1994 Computer tomography assisted laser intervention

Adam R. Mester, Ernoe Mako

Proceedings Volume 2084, Biomedical Optoelectronic Devices and Systems; (1994) https://doi.org/10.1117/12.167322
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary

Abstract

Radiological procedures to destroy deep neoplastic laesions of internal organs - without surgical exploration is a highly instnimentation dependent technique, reducing the risk for patients and the costs of hospitalisation. Nonturnor therapeutic radiology can be used for chernolysis: syrnpathectomy, discectorny, but there is a danger of complications because of uncontrolable fluid distribu— tion, wich can produce unexpected necrosis. Laser, guided by radiologiacal imaging methods, gives the possibility of precise intervention /nucleus pulposus denaturalisation or brain tumor fiber optic destruction, as introduced by Ascher/. Laser — intersti— tial — hypertherrnia is a new method /developed by Bown/ to increase the tumor destruction, and it promotes the effect of other anti— tumo r therapies, as radiotherapy, cytostatic therapy or photodynainic therapy. Photodynarnic therapy by systemic administration causes a skin photosensitivity for 30 — 40 days, and the hernatoporphyrin concentration in the tumor tissue is only 1 — 2 ,ug/g. Ideal application for deep tumor effective laser desstruction was developed by Gatenby: CT — guided fiberoptic direct injection of HpD prepared PDT. The direct HpD injection into the tumor reults 50 — 100 ,ug/g concentration of the photosensitiser in the tumor tissue, without systemic effects, as skin photosensitivity. That's, why the exposure can be repeated at weekly intervals. Under 2 cm size the results are excellent, but even larger masses, have had not respomided to conventional therapy showed significant improvement in size and in pain aswell. The procedure can be on outpatient basis

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Adam R. Mester and Ernoe Mako "Computer tomography assisted laser intervention", Proc. SPIE 2084, Biomedical Optoelectronic Devices and Systems, (1 February 1994); https://doi.org/10.1117/12.167322

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KEYWORDS

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Computed tomography

Therapeutics

Photodynamic therapy

Fiber optics

Laser therapeutics

Skin

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