Development and clinical evaluation of noninvasive near-infrared  monitoring of cerebral oxygenation

Yappa A.B.D. Wickramasinghe; Peter J. Rolfe; Keith Palmer; S. Watkins; S. A. Spencer; M. Doyle; S. O'Brien; A. Walker; C. Rice; C. Smallpeice

doi:10.1117/12.168758

15 February 1994 Development and clinical evaluation of noninvasive near-infrared monitoring of cerebral oxygenation

Yappa A.B.D. Wickramasinghe, Peter J. Rolfe, Keith Palmer, S. Watkins, S. A. Spencer, M. Doyle, S. O'Brien, A. Walker, C. Rice, C. Smallpeice

Author Affiliations +

Proceedings Volume 2085, Biochemical and Medical Sensors; (1994) https://doi.org/10.1117/12.168758
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary

Abstract

Near infrared spectroscopy (NIRS) is a relatively new method which is suitable for monitoring oxygenation in blood and tissue in the brain of the fetus and the neonate. The technique involves in-vivo determination of the absorption of light in the wavelength range 775 to 900 nm through such tissue and converting such changes in absorbance to provide information about the changes in the concentration of oxygenated and de-oxygenated haemoglobin (HbO₂ and Hb). Recent developments of the methodology now enable the calculation of changes in cerebral blood volume (CBV) as well as absolute CBV and cerebral blood flow (CBF). The attraction of this method is its applicability to monitor cerebral function in a wide variety of patient groups. Although primarily developed for neonatal use it is today applied on the fetus to investigate fetal hypoxia and on adults undergoing surgery.

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Yappa A.B.D. Wickramasinghe, Peter J. Rolfe, Keith Palmer, S. Watkins, S. A. Spencer, M. Doyle, S. O'Brien, A. Walker, C. Rice, and C. Smallpeice "Development and clinical evaluation of noninvasive near-infrared monitoring of cerebral oxygenation", Proc. SPIE 2085, Biochemical and Medical Sensors, (15 February 1994); https://doi.org/10.1117/12.168758

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