Cyanoacrylate skin surface stripping is a noninvasive method of examination in spatial organization of epidermis. Morphometrical analysis of keratinocytes nuclei in stained epidermal stripping can be used to determination of nuclei size and shape. With the help of karyometrycal analysis the spatial heterogeneity of psoriatic lesions structure was detected. The suggested method of karyometrycal analysis can be used to estimate psoriasis treatment effectiveness and to solve other research problems.
Sergei R. Utz, Sergei R. Utz,
"Exfoliative karyometry of the epidermis", Proc. SPIE 2100, Cell and Biotissue Optics: Applications in Laser Diagnostics and Therapy, (28 June 1994); doi: 10.1117/12.179004; https://doi.org/10.1117/12.179004