12 July 1994 Long-term healing of photodynamic therapy: treatment of experimental intimal hyperplasia
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Abstract
A study was performed to determine whether intimal hyperplasia can be chronically inhibited and the artery wall integrity maintained after cells are depleted from the artery with photodynamic therapy. Utilizing chloroaluminum sulfonated phthalocyanine or saline for control, limited balloon injury of the common carotid artery was performed before irradiation with 675 mm laser light. Results demonstrated carotid inhibition of intimal hyperplasia in PDT treated arteries without aneurysm formation or artery dilatation. By 4 weeks there was reendothelialization of the intima of the PDT arteries and repopulation of the adventitia with myofibroblasts. This data was encouraging in that PDT can chronically inhibit intimal hyperplasia without precipitating a weakness in the arterial wall.
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Glenn M. LaMuraglia, N. R. ChandraSekar, Thomas J. Flotte, Tayyaba Hasan, "Long-term healing of photodynamic therapy: treatment of experimental intimal hyperplasia", Proc. SPIE 2130, Diagnostic and Therapeutic Cardiovascular Interventions IV, (12 July 1994); doi: 10.1117/12.179926; https://doi.org/10.1117/12.179926
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