19 July 1994 Phototherapy of Barrett's esophagus
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Abstract
Barrett's esophagus is a common premalignant disease. The aim of this study is to determine if low dose photodynamic therapy is capable of ablating Barrett's epithelium allowing regrowth of normal squamous mucosa. Methods: Patients with specialized Barrett's esophagus of at least 3 cm length were given 1.5-1.75 mg/kg of hematoporphyrin derivative intravenously. After 48 hours, esophagoscopy and videotaping of the Barrett's was performed. A 1.0-1.5 cm cylindrical diffusing fiber delivered light of 630 nm in a dose of 150-200 J/cm using a tunable dye laser at a power of 400 mW/cm. Following entry, patients were placed on omeprazole 20 mg/day for six months. Results: Twelve patients (8 men) mean age of 62 +/- 4 have had repeat endoscopy performed at 25 +/- 2 weeks following entry. The Barrett's segment length decreased from 8+/- 1 to 5+/- 1 cm after PDT (p < 0.01) with a corresponding change in the appearance and location of the squamocolumnar junction. Six (50%) of the patients had a 4 cm or more decrease in the length of their Barrett's esophagus with normal squamous mucosa on biopsy. Adverse events included transient odynophagia, minor sunburn, and transient chest pain. Conclusions: Photodynamic therapy of Barrett's esophagus can cause a regression in length of the Barrett's segment with replacement by normal squamous epithelium.
© (1994) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Kenneth K. Wang, Kenneth K. Wang, Kumar Gutta, Kumar Gutta, Mark A. Laukka, Mark A. Laukka, } "Phototherapy of Barrett's esophagus", Proc. SPIE 2133, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy III, (19 July 1994); doi: 10.1117/12.179995; https://doi.org/10.1117/12.179995
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