19 May 1994 Early cancer diagnosis using a diode laser and fiber optic system
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Abstract
An ultrasensitive fiberoptic sensor using a near-IR fluorescence drug was developed for early cancer detection. Due to the use of long wavelength excitation at 670 nm with a diode laser, no measurable background fluorescence was observed. The system was built and successfully demonstrated in-vitro with a great drug sensitivity and tumor size resolution. The system, consisting of fiber probe, grating, and CCD optoelectronic components, is highly integrated. Based on fluorescence signature, tumors can be detected in real time. The flexible fiber with excellent light collection efficiency could be inserted into a human body through the working channel of an endoscope to map the metastatic region.
© (1994) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Winston Ho, Peter W. Low, "Early cancer diagnosis using a diode laser and fiber optic system", Proc. SPIE 2135, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases, (19 May 1994); doi: 10.1117/12.176010; https://doi.org/10.1117/12.176010
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