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19 May 1994 Noninvasive identification of bladder cancer with subsurface backscattered light
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We have developed and are testing early prototypes of an optical biopsy system (OBS) for detection of cancer and other tissue pathologies. The OBS invokes a unique approach to optical diagnosis of tissue pathologies based on the elastic scattering properties, over a wide range of wavelengths, of the microscopic structure of the tissue. Absorption bands in the tissue also add useful complexity to the spectral data collected. The data acquisition and storage/display time with the OBS instrument is approximately 1 second. Thus, in addition to the reduced invasiveness of this technique compared with current state-of- the-art methods, the OBS offers the possibility of impressively faster diagnostic assessment. The OBS employs a small fiber-optic probe that is amendable to use with any endoscope, catheter or hypodermic, or to direct surface examination (e.g., as in skin cancer or cervical cancer). We report here specifically on its potential application in the detection of bladder cancer.
© (1994) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Irving J. Bigio, Judith R. Mourant, James D. Boyer, Tamara M. Johnson, Tsutomu Shimada, and Richard L. Conn "Noninvasive identification of bladder cancer with subsurface backscattered light", Proc. SPIE 2135, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases, (19 May 1994);

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