19 May 1994 Noninvasive spectroscopic diagnosis of superficial ocular lesions and corneal infections
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Abstract
The potential of a rapid noninvasive diagnostic system to detect tissue abnormalities on the surface of the eye has been investigated. The optical scatter signal from lesions and normal areas on the conjunctival sclera of the human eye were measured in vivo. It is possible to distinguish nonpigmented pingueculas from other lesions. The ability of the system to detect malignancies could not be tested because none of the measured and biopsied lesions were malignant. Optical scatter and fluorescence spectra of bacterial and fungal suspensions, and corneal irritations were also collected. Both scattering and fluorescence show potential for diagnosing corneal infections.
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Judith R. Mourant, Irving J. Bigio, D. C. Gritz, Randolph D. Glickman, Tamara M. Johnson, Tsutomu Shimada, K. Story-Held, "Noninvasive spectroscopic diagnosis of superficial ocular lesions and corneal infections", Proc. SPIE 2135, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases, (19 May 1994); doi: 10.1117/12.176002; https://doi.org/10.1117/12.176002
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