19 May 1994 Time-resolved optical diffusion tomography
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Proceedings Volume 2135, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases; (1994); doi: 10.1117/12.175996
Event: OE/LASE '94, 1994, Los Angeles, CA, United States
Abstract
A mathematical model is proposed describing time-resolved output measurements obtained on the surface of a diffusely scattering body due to an input pulse of near-IR light at a different location also on the surface. Such measurements can be obtained using a pulsed near-IR laser coupled with a CCD streak camera. The scattering body is assumed to exhibit homogenous scattering and spatially varying absorption. Using this model, an iterative algorithm is derived using maximum likelihood methods that allows the reconstruction of the spatial absorption pattern from a set of time-resolved tomographic measurements. The methodology places no restrictions upon the time-of-arrival of the detected photons, thus permitting the entire time-resolved signal to be used in the reconstruction process. The reconstruction algorithm is easily initialized and preliminary results indicate that stable reconstructions can be performed.
© (1994) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
C. Robert Appledorn, Robert A. Kruger, Pingyu Liu, "Time-resolved optical diffusion tomography", Proc. SPIE 2135, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases, (19 May 1994); doi: 10.1117/12.175996; http://dx.doi.org/10.1117/12.175996
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KEYWORDS
Absorption

Reconstruction algorithms

Photons

Scattering

Algorithm development

Tissues

Light scattering

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