19 May 1994 Tissue autofluorescence spectroscopy: in-vivo alterations may reflect cellular proliferation
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Abstract
We report on the in vivo fluorescence spectroscopy of ten oral tongue cancers in previously untreated patients. Spectral profiles of the tongue tumor in each patient were compared to those of the corresponding normal contralateral oral tongue mucosa. Spectral characteristics were generated using a xenon lamp as a light source and the results described herein were restricted to one excitation scan obtained using a Mediscience-CD Scanner. The ratio of the main peak at 320-350 nm to the secondary peak at 373-376 nm and the area under the curve between 300 and 400 nm in the excitation scan were used as measurements to calculate differences between the normal versus oral tongue cancer. Significance was determined using the paired t-st. The ratio of the main peak to the secondary peak was higher in the tumor scans when compared to the corresponding contralateral mucosa. When the area under the curves was analyzed, the tumor tissue had reproducible lower values as compared to the contralateral normal sites.
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Howard E. Savage, Venkateswara Kolli, Jian Chung Zhang, Robert R. Alfano, Peter G. Sacks, Stimson P. Schantz, "Tissue autofluorescence spectroscopy: in-vivo alterations may reflect cellular proliferation", Proc. SPIE 2135, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases, (19 May 1994); doi: 10.1117/12.175991; https://doi.org/10.1117/12.175991
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