Instrument factors influencing the precision of measurement of clinical spectrometers

Gerald E. Cohn

doi:10.1117/12.180789

21 July 1994 Instrument factors influencing the precision of measurement of clinical spectrometers

Gerald E. Cohn

Proceedings Volume 2136, Biochemical Diagnostic Instrumentation; (1994) https://doi.org/10.1117/12.180789
Event: OE/LASE '94, 1994, Los Angeles, CA, United States

Abstract

Biomedical diagnostic systems perform as combinations of assay chemistry, sample handling, reagent addition, detection and data processing components. Modeling the response of an instrument's photonic detection subassembly provides a quantitative estimate of the minimum relative uncertainty in analyte concentration. Limits on the operating range for which the relative uncertainty falls within specified uncertainty boundaries also follow from this analysis. The present study examines the optimal uncertainty in spectrophotometric measurements for different models of detector response. For the constant uncertainty model the operating range which corresponds to relative uncertainty no greater than twice the minimum value extends from A approximately equals 0.07 to A approximately equals 0.79. A PMT-like response results in the limits A approximately equals 0.2 to A approximately equals 2.3.

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Gerald E. Cohn "Instrument factors influencing the precision of measurement of clinical spectrometers", Proc. SPIE 2136, Biochemical Diagnostic Instrumentation, (21 July 1994); https://doi.org/10.1117/12.180789

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