In this paper, we present our approach to developing Global Picture Archiving and Communication System (GPACS) applications using the Open Software Foundation (OSF) Distributed Computing Environment (DCE) services and toolkits. The OSF DCE services include remote procedure calls, naming service, threads service, time service, file management services, and security service. Several OSF DCE toolkits are currently available from computer and software vendors. Designing distributed Global PACS applications using the OSF DCE approach will feature an open architecture, heterogeneity, and technology independence for GPACS remote consultation and diagnosis applications, including synchronized image annotation, and system privacy and security. The applications can communicate through various transport services and communications networks in a Global PACS environment. The use of OSF DCE services for Global PACS will enable us to develop a robust distributed structure and new user services which feature reliability and scalability for Global PACS environments.