Absolute volumetric blood flow quantification in rabbit brain using digital subtraction angiography

Atila Ersahin; Sabee Y. Molloi; James W. Hicks; Yao-Jin Qian

doi:10.1117/12.174400

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1 May 1994 Absolute volumetric blood flow quantification in rabbit brain using digital subtraction angiography

Atila Ersahin, Sabee Y. Molloi, James W. Hicks, Yao-Jin Qian

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Proceedings Volume 2168, Medical Imaging 1994: Physiology and Function from Multidimensional Images; (1994) https://doi.org/10.1117/12.174400
Event: Medical Imaging 1994, 1994, Newport Beach, CA, United States

Abstract

An angiographic method using first pass distribution analysis (FPA) has been investigated for determining instantaneous absolute volumetric blood flow in an angiographic perfusion phantom and in a rabbit animal model following intra-arterial injection of contrast material. The method is based on the concept of conservation of contrast material in successive angiographic images, utilizing the videodensitometric information in the arterial bed. The volume of contrast material entering the perfusion bed between two successive images was determined using videodensitometric and entrance vessel calibration techniques. In phantom studies, measured (M) and known (K) mean flow rates were related with videodensitometric and entrance vessel calibration techniques, respectively. In vivo, measured and known flow rates in the left common carotid artery of two rabbits were related with the videodensitometric and the entrance vessel calibration techniques, respectively. The results of this study demonstrated the potential utility of the FPA algorithm in conjunction with digital substraction angiography for measuring phasic blood flow.

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Atila Ersahin, Sabee Y. Molloi, James W. Hicks, and Yao-Jin Qian "Absolute volumetric blood flow quantification in rabbit brain using digital subtraction angiography", Proc. SPIE 2168, Medical Imaging 1994: Physiology and Function from Multidimensional Images, (1 May 1994); https://doi.org/10.1117/12.174400

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