1 May 1994 Feasibility of using high-speed electron beam x-ray CT (EBCT) to follow the time course of the pulmonary response to pneumonectomy in rabbits
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Abstract
This report focuses on preliminary experiments designed to determine regional blood flows and air, blood, and tissue contents at end expiratory lung volume in anesthetized, paralyzed, normal, sham-operated, and pneumonectomized (left lung removed) rabbits with and without wax plombage. High temporal resolution measurements were made with an EBCT scanner during the mechanical injection of a bolus of radiopaque contrast material into the pulmonary vasculature. The time-intensity curves of selected lung regions were analyzed with VIDAR using a modification of the myocardial blood flow model proposed by Wolfkiel et al. The resulting data provided an estimate of regional blood flow and total and regional air, blood and `tissue' contents, where `tissue' represents intracellular and interstitial water, i.e., lung water exclusive of blood. The estimates of mean lung air, blood and tissue contents were similar across groups and consistent with anticipated results.
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L. E. Olson, L. E. Olson, V. P. Wright, V. P. Wright, Eric A. Hoffman, Eric A. Hoffman, } "Feasibility of using high-speed electron beam x-ray CT (EBCT) to follow the time course of the pulmonary response to pneumonectomy in rabbits", Proc. SPIE 2168, Medical Imaging 1994: Physiology and Function from Multidimensional Images, (1 May 1994); doi: 10.1117/12.174408; https://doi.org/10.1117/12.174408
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