1 May 1994 Imaging-based assessment of dyspnea in cigarette smokers
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Patients with pulmonary fibrosis frequently smoke cigarettes. The cause of dyspnea in these patients is often complex because of the coexistence of multiple disease processes. We investigated 10 cigarette smokers with pulmonary fibrosis who were referred for evaluation of new onset or worsening dyspnea. Chest radiographs and pulmonary function tests were obtained in addition to high-resolution computed tomography (HRCT). In those patients with HRCT evidence of both diseases, spirometry and lung volumes were most often normal. Although plain films provided a reasonable assessment of fibrosis, they underestimated the severity of emphysema. Quantitation of both emphysema and fibrosis by HRCT was reproducible and correlated with key pulmonary function tests. Our findings indicate that the HRCT scan is a useful diagnostic test in patients with pulmonary fibrosis who are also cigarette smokers.
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Jeffrey R. Galvin, Paul J. Chang, David A. Schwartz, Gary W. Hunninghake, Richard Helmers, Masaki Mori, "Imaging-based assessment of dyspnea in cigarette smokers", Proc. SPIE 2168, Medical Imaging 1994: Physiology and Function from Multidimensional Images, (1 May 1994); doi: 10.1117/12.174404; https://doi.org/10.1117/12.174404

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