1 March 1995 Experimental research of the possible use of photodynamic methods in the treatment of melanoma of the iris
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Proceedings Volume 2203, Laser Technology IV: Applications in Medicine; (1995) https://doi.org/10.1117/12.203328
Event: Laser Technology: Fourth Symposium, 1993, Szczecin, Poland
Abstract
In our experimental work we present the use of hematoporphyrin derivative photodynamic therapy (HpD-PDT) in the treatment of melanoma. Eighteen eyes of rabbits were incubated intracamerally with amelanotic Greene melanoma tissue. The technique involves the administration of HpD and photoactivation of tumor with red light (630 nm) to achieve selective destruction of cancer cells. After photoradiation the tumor showed blanching and shrinkage, we could also observe the tumor vasculature damaged. Successfully treated tumors had large areas of necrosis with severely damaged blood vessels in histopathological examination. Results indicate that HpD-PDT is a very promising modern modality offering a new method of melanoma treatment.
© (1995) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Tadeusz Kecik, Tadeusz Kecik, Iwona Switka-Wieclawska, Iwona Switka-Wieclawska, Jan Kasprzak, Jan Kasprzak, Alfreda Graczyk, Alfreda Graczyk, Antoni Pratnicki, Antoni Pratnicki, } "Experimental research of the possible use of photodynamic methods in the treatment of melanoma of the iris", Proc. SPIE 2203, Laser Technology IV: Applications in Medicine, (1 March 1995); doi: 10.1117/12.203328; https://doi.org/10.1117/12.203328
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