8 June 1994 Advanced optics module for monitoring protein crystal growth in microgravity
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Abstract
Understanding the phenomena of protein crystal growth has become a critical factor in the advancement of fundamental life sciences. To characterize this process, sensitive non-intrusive monitoring systems must be utilized in a micro-gravity environment. We believe detailed optical monitoring to be the superior technique for use in micro-gravity. The proposed approach includes monitoring the nucleation event, rate and form of crystal growth, and protein density variations throughout the cell volume with four different optical metrology methods running concurrently. The system will incorporate photon correlation spectroscopy, interferometry, Zernike phase contrast imagery, and high-resolution polarization microscopy. These four systems have all been combined into a single optical module that provides crystal growth process data. The module utilizes the emerging technologies of binary optics and solid optics to shrink and stabilize the system (patent-pending).
© (1994) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Alan D. Kathman, Tammy C. Cole, Mark E. Wells, Greg Jenkins, Stan Koszelak, Alexander McPherson, "Advanced optics module for monitoring protein crystal growth in microgravity", Proc. SPIE 2214, Space Instrumentation and Dual-Use Technologies, (8 June 1994); doi: 10.1117/12.177668; https://doi.org/10.1117/12.177668
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KEYWORDS
Crystals

Proteins

Solids

Phase contrast

Microscopy

Polarization

Interferometry

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