Advanced optics module for monitoring protein crystal growth in microgravity

Alan D. Kathman; Tammy C. Cole; Mark E. Wells; Greg Jenkins; Stan Koszelak; Alexander McPherson

doi:10.1117/12.177668

8 June 1994 Advanced optics module for monitoring protein crystal growth in microgravity

Alan D. Kathman; Tammy C. Cole; Mark E. Wells; Greg Jenkins; Stan Koszelak; Alexander McPherson

Author Affiliations +

Proceedings Volume 2214, Space Instrumentation and Dual-Use Technologies; (1994) https://doi.org/10.1117/12.177668
Event: SPIE's International Symposium on Optical Engineering and Photonics in Aerospace Sensing, 1994, Orlando, FL, United States

Abstract

Understanding the phenomena of protein crystal growth has become a critical factor in the advancement of fundamental life sciences. To characterize this process, sensitive non-intrusive monitoring systems must be utilized in a micro-gravity environment. We believe detailed optical monitoring to be the superior technique for use in micro-gravity. The proposed approach includes monitoring the nucleation event, rate and form of crystal growth, and protein density variations throughout the cell volume with four different optical metrology methods running concurrently. The system will incorporate photon correlation spectroscopy, interferometry, Zernike phase contrast imagery, and high-resolution polarization microscopy. These four systems have all been combined into a single optical module that provides crystal growth process data. The module utilizes the emerging technologies of binary optics and solid optics to shrink and stabilize the system (patent-pending).

Citation Download Citation

Alan D. Kathman, Tammy C. Cole, Mark E. Wells, Greg Jenkins, Stan Koszelak, Alexander McPherson, "Advanced optics module for monitoring protein crystal growth in microgravity", Proc. SPIE 2214, Space Instrumentation and Dual-Use Technologies, (8 June 1994); doi: 10.1117/12.177668; https://doi.org/10.1117/12.177668

ACCESS THE FULL ARTICLE

PERSONAL SIGN IN
Full access may be available with your subscription

Email or Username Forgot your username?

Password Forgot your password?

Show

Remember Email/Username on this computer

Remember Password

No SPIE account? Create an account
or Institutional Sign In via Shibboleth

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $14.40

Non-members: $18.00 ADD TO CART

Show All Keywords

Keywords/Phrases

Search In:

Publication Years